How To Use JANUS

XELJANZ (tofacitinib) Clinical Trials Data

JANUS is a subgroup data visualization tool designed to provide tofacitinib (Xeljanz®) efficacy and safety outcomes from clinical trials (Rheumatoid Arthritis) by user selected * clinical trial patient subgroup(s) and displayed in real-time. This is not intended to be used for the management of any individual patient in a clinical setting. JANUS is also not to be used as research tool. JANUS is a post-hoc subgroup data visualization tool for educational purposes only.

*Clinical characteristics and efficacy and safety outcomes are pre-defined based on clinical trial information captured in the tofacitinib clinical development program.

Get started with JANUS

Once you have chosen the U.S. Healthcare Professional category you will see the Filters section.

The filter page shows objective patient criteria, organized in three categories that can be manually selected to create specific subgroups. The three categories are:

Patient Demographics
Medical History
RA Medication

The total number of patients and a percentage of the total population is automatically changing based on the selected patient characteristics. Each criteria selection will accordingly update the visual data representation on the Safety and Efficacy tabs.

NOTE: If none of the input criteria are selected, all data available (100%) will be shown.

You can use the tab bar to switch between Filters, Safety, and Efficacy data figures.

Safety

The safety figures represent the incidence rate per 100 patient years for the tofacitinib groups:

Tofacitinib 5mg twice daily
Tofacitinib 10mg twice daily
Combined Doses

NOTE: Display of safety data is contingent upon the subgroup meeting sufficient predefined criteria based on exposure duration.

Efficacy

The efficacy data represent disease activity scores for the tofacitinib treatment groups:

Tofacitinib 5mg twice daily
Tofacitinib 10mg twice daily
Combined Doses

NOTE: Display of efficacy data is contingent upon the subgroup meeting sufficient predefined criteria based on patient count. The number of patients in efficacy data may vary from the total number in the selected subgroup because of missing or irrelevant data collection.

Navigation

Header Navigation Menu:
The top navigation menu is an organized list of links to navigate the supporting JANUS web pages. The menu appears in the page header so that users can access the most useful pages quickly.

Home - to go directly to the Filters section.
About JANUS - general user information about JANUS.
How to Use - user guide.
FAQ - most frequently asked questions.

Footer Navigation Menu:
The bottom navigation menu is a list of reference links to dedicated Pfizer web pages. The menu appears in the page footer so that users can access the following Pfizer resources: